Myocardial Ischemia
Insulin-like growth factor gene transfer rejuvenates the injured heart
Published in Gene Therapy Weekly, April 3rd, 2003
"We have characterized the effect of recombinant insulin-like growth factor (IGF) proteins, as well as third-generation adenoviral vectors encoding either IGF-I or IGF-II genes, on cardiomyocyte apoptosis and on angiogenesis," announced E.J. Su, an investigator at Genetic Therapy, Inc., in Gaithersburg, Maryland.
Su's team, collaborating with colleagues from Novartis, studied IGF-I and -II gene transfer in cultured cells and in an in vivo Matrigel model.
"We found that...
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Source: Gene Therapy Weekly (2003-04-03)
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