Cancer Gene Therapy
E1A sensitizes cells to TNF alpha by downregulating c-FLIP gene
Published in Gene Therapy Weekly, April 10th, 2003
"Tumor necrosis factor alpha (TNF-alpha) activates both apoptosis and NF-kappaB-dependent survival pathways, the former of which requires inhibition of gene expression to be manifested. c-FLIP is a TNF-alpha-induced gene that inhibits caspase-8 activation during TNF-alpha signaling," explained wrote D. Perez and colleagues, Rutgers State University.
"Adenovirus infection and E1A expression sensitize cells to TNF-alpha by allowing apoptosis in the absence of inhibitors of gene expression, suggesting that it may be disabling a survival...
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Source: Gene Therapy Weekly (2003-04-10)
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