Published in Gene Therapy Weekly, April 10th, 2003
"To reduce cellular damage by pronuclear microinjection and nuclear transfer, we have recently developed a vibratory microinjection method," according to researchers in Japan.
"A micropipette was fixed to a piezoelectric ceramic with a resonance frequency of 70 kHz. When this micropipette was vibrated, it easily entered a mouse-fertilized egg without any sharp depression of the cell body, whereas a sharp, deep depression at the insertion site was observed when the micropipette was not vibrated," reported F. Miyawaki and colleagues, Tokyo Denki University.
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