Published in Gene Therapy Weekly, April 10th, 2003
"RNA interference (RNAi) is a RNA-mediated sequence-specific gene silencing mechanism. Recently, this mechanism has been used to down-regulate protein expression in mammalian cells by applying synthetic- or vector-generated small interfering RNAs (siRNAs). However, for the evaluation of this new knockdown technology, it is crucial to demonstrate biological consequences beyond protein level reduction," researchers in Germany report.
"Here, we demonstrate that this new siRNA-based technology is suitable to analyze protein functions using the phosphatidylinositol (PI) 3-kinase...
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