Cystic Fibrosis
Neutral, pegylated gene lipoplexes achieve better degree of transfection
Published in Gene Therapy Weekly, May 1st, 2003
A possible obstruction to gene transfection is the thick mucus secretions in the conductive airways of cystic fibrosis (CF) patients. Recently, N.N. Sanders and colleagues, State University of Ghent, Netherlands, assessed "the diffusion of nanospheres and cationic DOTAP lipoplexes through CF sputum and the influence of CF mucus components on the physicochemical properties and gene expression of cationic DOTAP lipoplexes and neutral, pegylated GL67 lipoplexes."
Getting the particles through the sputum was, indeed, a challenge. "The number of particles...
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Source: Gene Therapy Weekly (2003-05-01)
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