Myasthenia Gravis
Efficacious mRNA-targeted therapies hold some advantages
Published in Gene Therapy Weekly, May 1st, 2003
"Alternative splicing induces, under abnormal cholinergic neurotransmission, overproduction of the rare 'readthrough' acetylcholinesterase (AChE) variant AChE-R. We explored the pathophysiological relevance of this phenomenon in patients with myasthenia gravis (MG) and rats with experimental autoimmune MG (EAMG), neuromuscular junction diseases with depleted acetylcholine receptors," said T. Brenner and colleagues, Hebrew University of Jerusalem.
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Source: Gene Therapy Weekly (2003-05-01)
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