Retinal Dystrophy
Researchers caution against intraocular CNTF gene therapy
Published in Gene Therapy Weekly, May 1st, 2003
"Intraocular delivery of a variety of neurotrophic factors has been widely investigated as a potential treatment for retinal dystrophy (RD). The most commonly studied factor, ciliary neurotrophic factor (CNTF), has been shown to preserve retinal morphology and to promote cell survival in a variety of models of RD," wrote F.C. Schlichtenbrede and colleagues.
They used adeno-associated virus (AAV)-mediated gene delivery in one group of Prph2(Rd2/Rd2) mice and AAV-mediated gene delivery...
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Source: Gene Therapy Weekly (2003-05-01)
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