Breast Cancer Vaccine

Vaccine elicits tumor-specific antibodies in patients with breast cancer

Published in Gene Therapy Weekly, May 8th, 2003

Researchers have identified tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells.

"Thirty HLA-A2+ women with metastatic breast cancer received up to 14 vaccinations with MDA-MB-231-CD80, an HLA-A2+ allogeneic breast cancer cell line, which had been lipofected with the cDNA for the CD80 costimulatory molecule. Tumor cells were administered with BCG or GM-CSF as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to tumor cell lysate, MUC1, HER2/neu and p53," scientists in the United States and the Netherlands report.

"Since the cell line was grown in fetal bovine...

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Source: Gene Therapy Weekly (2003-05-08)

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