Oncology

Heat-directed suicide gene therapy reduces breast cancer cell survival

Published in Gene Therapy Weekly, May 8th, 2003

by Sonia Nichols, senior medical writer-Scientists in Ontario, Canada have discovered that heat-directed suicide gene therapy can reduce breast cancer cell survival.

Researchers at the University of Toronto and Ontario Cancer Institute believe that treatment strategies combining gene therapy with heat could prove beneficial for overcoming the heat or radiation resistance of certain breast cancers.

"Previously, we demonstrated that infection of human breast cancer cells with a recombinant adenovirus expressing beta-galactosidase from the human heat shock protein (hsp)70b gene promoter (Ad.70b.betagal) results in 50- to 800-fold increases in reporter...

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Source: Gene Therapy Weekly (2003-05-08)

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