Cancer Therapy
An Ets-1 dominant-negative mutant disturbs normal and tumor angiogenesis
Published in Gene Therapy Weekly, May 15th, 2003
"We and others have shown that members of the Ets family of transcription factors are involved in morphogenic properties of endothelial cells in vitro. To investigate the role of these factors in the transcriptional regulation of angiogenesis in vivo, we set up a nontraumatic model that allows daily macroscopic examination of both growth factor- and tumor-induced angiogenesis in mouse ears," according to researchers reporting in the journal Oncogene.
"In the same animal, we were thus able to record variations in the patterns of neovessels induced and cell populations...
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Source: Gene Therapy Weekly (2003-05-15)
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