Gene Vectors

A new intracellular delivery system propels antisense molecules

Published in Gene Therapy Weekly, May 15th, 2003

A new intracellular delivery system propels antisense molecules to their target.

"An antisense oligonucleotide (ODN), c-myb, was covalently conjugated to poly(ethylene glycol) (PEG) via an acid-cleavable phosphoramidate linkage to form a diblock copolymer-like structure. The phosphoramidate linkage between ODN and PEG was completely cleaved within 5 hours in an endosomal acidic condition (pH 4.7)," scientists in South Korea reported.

"When complexed with a cationic fusogenic peptide, KALA, the ODN/PEG conjugate self-associated to form polyelectrolyte complex micelles in an aqueous solution. The anionic ODN segments were ionically interacted with...

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Source: Gene Therapy Weekly (2003-05-15)

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