Neuroscience

Genes that control the cell cycle cause neuronal death after spinal injury

Published in Gene Therapy Weekly, May 22nd, 2003

Genes that control the cell cycle cause neuronal death after spinal injury.

"Spinal cord injury causes secondary biochemical changes leading to neuronal cell death. To clarify the molecular basis of this delayed injury, we subjected rats to spinal cord injury and identified gene expression patterns by high-density oligonucleotide arrays (8,800 genes studied) at 30 minutes, 4 hours, 24 hours, or 7 days after injury (total of 26 U34A profiles). Detailed analyses were limited to 4300 genes consistently expressed above background," scientists writing in the journal Annals of Neurology reported.

"Temporal clustering showed rapid expression of...

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Source: Gene Therapy Weekly (2003-05-22)

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