Vector Development

Gastroenteritis virus genome engineered as expression vector inducing immunity

Published in Gene Therapy Weekly, May 22nd, 2003

Researchers have engineered the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity.

"The genome of the coronavirus transmissible gastroenteritis virus (TGEV) has been engineered as an expression vector with an infectious cDNA. The vector led to the efficient (>40 microgram/10⁶ cells) and stable (>20 passages) expression of a heterologous gene (green fluorescent protein [GFP]), driven by the transcription-regulating sequences (TRS) of open reading frame (ORF) 3a inserted in the site previously occupied by the nonessential ORFs 3a and 3b," scientists writing in the Journal of Virology report.

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Source: Gene Therapy Weekly (2003-05-22)

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