Respiratory Medicine

Steroids stop complications linked to gene therapy in donated lungs

Published in Gene Therapy Weekly, May 22nd, 2003

by Sonia Nichols, senior medical writer - Methylprednisolone reduces the inflammation associated with adenoviral-delivered human interleukin-10 (AdhIL-10) in donor lungs.

According to researchers in Toronto, Ontario, Canada, interleukin-10 (IL-10) gene expression in donor lungs improves post-transplantation lung function. However, immune response to adenovirus can generate an early proinflammatory response that may cause tissue damage before sufficient levels of IL-10 can be generated. Using rat lung transplant models, they have determined that methylprednisolone can lessen that inflammatory response, allowing enough time for appropriate IL-10 expression, and reducing...

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Source: Gene Therapy Weekly (2003-05-22)

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