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Leukemia

Translation-related genes predict the course of chronic lymphocytic leukemia

Published in Gene Therapy Weekly, May 22nd, 2003

Translation-related genes predict the course of chronic lymphocytic leukemia.

According to recent research from Germany, "B-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course. Recent studies have shown that CD38 surface expression on the malignant cell clone may serve as a prognostic marker in that CD38(+) patients with B-CLL are characterized by advanced disease stage, lesser responsiveness to chemotherapy, and shorter survival than CD38(-) patients."

"To further investigate the molecular phenotype of these two clinical subgroups, we compared the gene expression profiles of CD38(+) (n = 25)...

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