Gene Transfer
Calcium and ligands make stabilized plasmid-lipid particles potent transfectors
Published in Gene Therapy Weekly, May 29th, 2003
According to recent research from Canada, "recent work has shown that plasmid DNA can be efficiently encapsulated in well-defined 'stabilized plasmid-lipid particles' (SPLP) that have potential as systemic gene therapy vehicles [Gene Ther, 1999;6:271]. In this work, we examine the influence of ligands that enhance cellular uptake on the transfection potency of SPLP."
"The ligand employed is a cationic poly(ethylene glycol) (PEG) lipid (CPL) consisting of a lipid anchor and a PEG(3400) spacer chain with four positive charges at the end of the PEG (CPL4),"...
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Source: Gene Therapy Weekly (2003-05-29)
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