Respiratory Disease
Antioxidants and intraliposomal growth factor enhance lung cell transfection
Published in Gene Therapy Weekly, May 29th, 2003
"We hypothesized that constitutive formation of reactive oxygen species by respiratory cells is a barrier to gene transfer when liposome-DNA complexes are used, by contributing to rapid degradation of plasmid DNA. When plasmid DNA is complexed to liposomes it is protected against H2O2-mediated degradation but not that mediated by the hydroxyl radical. Treatment of distal rat fetal lung epithelial cells (RFL(19)Ep) with the vitamin E analog Trolox (50 micro M) reduced intracellular plasmid degradation," scientists writing in the American Journal of Physiology - Lung Cellular and Molecular...
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Source: Gene Therapy Weekly (2003-05-29)
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