Published in Gene Therapy Weekly, May 29th, 2003
"We hypothesized that constitutive formation of reactive oxygen species by respiratory cells is a barrier to gene transfer when liposome-DNA complexes are used, by contributing to rapid degradation of plasmid DNA. When plasmid DNA is complexed to liposomes it is protected against H2O2-mediated degradation but not that mediated by the hydroxyl radical. Treatment of distal rat fetal lung epithelial cells (RFL(19)Ep) with the vitamin E analog Trolox (50 micro M) reduced intracellular plasmid degradation," scientists writing in the American Journal of Physiology - Lung Cellular and Molecular...
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