Hepatitis C Virus
RNA aptamers inhibit HCVNS3 protease
Published in Gene Therapy Weekly, June 5th, 2003
"Non-structural protein 3 (NS3) of hepatitis C virus (HCV) has two distinct activities, protease and helicase, which are essential for HCV proliferation. In previous work, we obtained RNA aptamers (G9-I, II and III) which specifically bound the NS3 protease domain (DeltaNS3), efficiently inhibiting protease activity in vitro. To utilize these aptamers in vivo, we constructed a G9 aptamer expression system in cultured cells, using the cytomegarovirus enhancer + chicken beta-actin globin (CAG) promoter," scientists in Japan report.
"By conjugating the cis-acting genomic human hepatitis delta virus (HDV) ribozyme...
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Source: Gene Therapy Weekly (2003-06-05)
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