Published in Gene Therapy Weekly, June 5th, 2003
"While antibiotic selection has been routinely used for the selection of genetically modified cells, administration of cytotoxic drugs often leads to deleterious effects not only to inert cells but also to transfected or transduced ones," researchers in Japan report.
"In this study, we propose an antigen-mediated genetically modified cell amplification (AMEGA) system employing antibody/receptor chimeras without antibiotic selection," wrote M. Kawahara and colleagues, University of Tokyo, Graduate School Engineering.
"Based on a rational design where the...
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