Apoptosis

Tiny protein prevents disease-related cell death

Published in Gene Therapy Weekly, June 5th, 2003

Researchers at the Burnham Institute have found that humanin, a small, 24-amino acid protein recently discovered in studies of Alzheimer disease, suppresses activation of the protein Bax.

Bax triggers pathologic cell death in a number of diseases, including Parkinson, stroke, heart attack, and degeneration of ovaries during menopause.

These results, published online May 4, 2003, in Nature, suggest a novel target for therapeutic design based on inhibiting the cell destructive activity of Bax.

Bax protein is known to promote apoptosis latent in all cells. It does so by attacking the cell's powerhouse, the mitochondria,...

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Source: Gene Therapy Weekly (2003-06-05)

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