Transfection
Bfl-1 gene coexpression enhances response to HSV-thymidine kinase gene therapy
Published in Gene Therapy Weekly, June 12th, 2003
"Anticancer suicide gene therapy using herpes simplex virus-thymidine kinase (HSV-tk) and ganciclovir (GCV) features the unique advantage of being able to elicit brisk host immune response against tumors and the host response reportedly can be potentiated with the coexpression of other appropriate immune- or apoptosis-related genes. We introduced a novel antiapoptotic gene, bfl-1, to test its applicability in the HSV-tk/GCV system," scientists in South Korea reported.
"CT-26 murine colon cancer cells transfected with HSV-tk, alone or in combination with bcl-xL or...
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Source: Gene Therapy Weekly (2003-06-12)
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