Bioengineering
Alkylating polyamide inhibits transcription at specific coding sequences
Published in Gene Therapy Weekly, June 12th, 2003
"Transcription from DNA sequence-specifically alkylated by a hairpin polyamide (ImPyPy-gamma-ImPyLDu86, 1) was investigated. High-resolution polyacrylamide gel electrophoresis demonstrated that conjugate 1 alkylated a 993-bp DNA fragment, in accordance with the Py-Im recognition rule, predominantly at the one match site on the GFP-encoding strand and at four sites (I'-IV') on the noncoding strand. Alkylation of DNA inhibited the formation of full-length mRNA and caused the transcription of truncated mRNA," researchers in Japan reported.
"Polyacrylamide gel electrophoresis...
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Source: Gene Therapy Weekly (2003-06-12)
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