Gene Silencing
Vector-based RNA interference knocks down genes associated with angiogenesis
Published in Gene Therapy Weekly, June 19th, 2003
"Vascular endothelial growth factor (VEGF) carries out multifaceted functions in tumor development, and it exists as at least five isoforms with distinct biologic activities and clinical implications. Several strategies have been developed to block VEGF for cancer therapy; however, the approach to target-specific VEGF isoform(s) has not been explored to date," according to investigators in the United States.
"In the present study, we show that DNA vector-based RNA interference (RNAi), in which RNAi sequences targeting murine VEGF isoforms are inserted downstream of an RNA...
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Source: Gene Therapy Weekly (2003-06-19)
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