Bioengineering
Eurkaryotes secrete functionally active immunotoxins under the right conditions
Published in Gene Therapy Weekly, June 19th, 2003
According to recent research published in the journal Protein Expression and Purification, "immunotoxins consist of a target-cell-specific binding moiety, chemically or recombinantly linked to a cytotoxic component. A number of different immunotoxins (IT) have increasingly been evaluated for immunotherapy. Since these foreign proteins are highly immunogenic in human, we have developed recombinant IT using the human ribonuclease angiogenin."
"Due to their potential toxic effects on eukaryotic cells, these IT are usually expressed in bacteria. Depending on the...
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Source: Gene Therapy Weekly (2003-06-19)
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