Retinopathy

Downregulation of fibronectin reduces vascular lesions in rodent retinas

Published in Gene Therapy Weekly, July 3rd, 2003

According to published research from the United States, "overexpression of extracellular matrix (ECM) components is closely associated with the development of vascular basement membrane (BM) thickening, a histological hallmark of diabetic microangiopathy."

"To determine whether BM thickening of retinal capillaries could be prevented by down regulating synthesis of fibronectin, an ECM component, we used antisense oligos targeted against translation initiation site of the fibronectin transcript in the galactose-fed rat, an animal model of diabetic retinopathy. After 2 months of galactose-feeding, intravitreal administration of 3 micromol/l antisense fibronectin oligos was...

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Source: Gene Therapy Weekly (2003-07-03)

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