Nephrology

Ultrasound-microbubble mediated gene transfer ameliorates renal fibrosis

Published in Gene Therapy Weekly, July 3rd, 2003

by Sonia Nichols, senior medical writer - Ultrasound-microbubble mediated renal cell transfection reduces renal fibrosis in study animals, according to researchers at Baylor College of Medicine in Houston, Texas.

Microbubbles are used as contrast agents for ultrasound imaging and are particularly valuable for targeting selected tissues and for providing useful information about the efficacy of chemotherapy. Medical investigators say an ultrasound-microbubble-mediated system (Optison) enhances gene therapy targeting transforming growth factor (TGF)-beta in the kidneys of rodents.

"Transforming growth factor (TGF)-beta is a key mediator in renal...

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Source: Gene Therapy Weekly (2003-07-03)

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