Published in Gene Therapy Weekly, July 10th, 2003
"Matrix metalloproteinases (MMPs) and integrins are essential for cell and extracellular matrix homeostasis. Both membrane type-1 MMP (MT1-MMP) and the integrin alphaV subunit are fully activated upon cleavage at a furin recognition site. Furin is shuttled to the cell surface through the trans-Golgi network and endosomal system, and its only known role on plasma membrane consists in activation of opportunistic pathogenic entities," scientists writing in the Journal of Cell Science report.
"Here, we report findings about the interaction of furin with MT1-MMP and the...
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