Published in Gene Therapy Weekly, July 10th, 2003
The patent specifically covers the use of the Gag polyprotein to mediate the packaging of functional reverse transcriptase (RT) and integrase (IN) independently of native Gag-Pol expression. RT and IN are normally expressed as components of the Gag-Pol precursor protein in replication-competent viruses. Since this invention enables functional RT and IN to be...
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