Pulmonary Hypertension
Angiopoietin-1 improves the hemodynamics of lungs under vascular distress
Published in Gene Therapy Weekly, July 10th, 2003
According to a study from Canada, "angiopoietin-1 (Ang-1), a newly discovered ligand of the endothelial-specific tyrosine kinase receptor Tie-2, has been found to promote cell survival, vascular maturation, and stabilization. We hypothesized that Ang-1 gene transfer to the pulmonary microcirculation would improve pulmonary hemodynamics and vascular remodeling in experimental pulmonary hypertension. Rat pulmonary artery smooth muscle cells were transfected with Ang-1 cDNA or null (pFLAG-CMV-1) vector."
"Syngeneic Fisher 344 rats were treated with monocrotaline (MCT) (75 mg/kg...
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Source: Gene Therapy Weekly (2003-07-10)
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