Virology
Modified feline immunodeficiency virus may be a useful gene therapy vector
Published in Gene Therapy Weekly, July 10th, 2003
"FIV-based lentiviral vector has shown a unique opportunity as an efficient gene delivery vehicle, especially to nondividing human cells. Here, we genetically reconstructed the FIV-based vector by serially deleting residual virus genes of gag and vif, leading to minimized cytotoxicity together with efficient virus production and gene transfer," scientists writing in the journal Virus Research reported.
"The modified FIV- based vector was generated by transiently transfecting 293T cells with three plasmids of the gene transfer vector with minimal gag region, the...
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Source: Gene Therapy Weekly (2003-07-10)
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