Published in Gene Therapy Weekly, July 17th, 2003
"Adenovirus (Ad)-specific T-cell responses in healthy adult donors were investigated. Ad5, inactivated by methylene blue plus visible light, induced proliferation and gamma interferon (IFN-gamma) production in peripheral blood mononuclear cells of the majority of donors. Responding T cells were CD4+ and produced IFN-gamma upon restimulation with infectious Ad5 and Ads of different subgroups," scientists writing in the Journal of Virology reported.
"T-cell clones showed distinct cross-reactivity patterns recognizing Ad serotypes from either one subgroup (C), two...
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