Gene Transport Systems
New cationic lipids with photocleavable spacers enhance transfection efficiency
Published in Gene Therapy Weekly, July 17th, 2003
According to published research from Japan, "new cationic lipids having an o-nitrobenzyl moiety as a photocleavable spacer between its hydrophilic and hydrophobic region were synthesized. To improve the efficiency of transfection with lipoplexes, after transfecting the cationic lipid aggregate/DNA complex, photoirradiation was performed."
"Photochemical decomposition of lipids would not only make the vector's membrane unstable to facilitate the fusion with endocytic vesicles, but also promote dissociation of cationic lipid-DNA complex, thus aiding the escape of DNA from...
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Source: Gene Therapy Weekly (2003-07-17)
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