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Gene Transfer

DNA condensation may be a limiting factor in lipid-based gene delivery

According to a study from the United States, "Cationic liposomes (CLs) are used worldwide as gene vectors (carriers) in nonviral clinical applications of gene delivery, albeit with unacceptably low transfection efficiencies (TE). We present three-dimensional laser scanning confocal microscopy studies revealing distinct interactions between CL-DNA complexes, for both lamellar L-alpha(C) and inverted hexagonal H-II(C) nanostructures, and mouse fibroblast cells. Confocal images of L complexes in cells identified two regimes."

"For low membrane charge density (sigma_M ),...

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