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Hepatitis B Virus Therapy
Short interfering RNA knocks out hepatitis B virus replication
July 24th, 2003
Short interfering RNA knocks out hepatitis B virus replication. According to a study from Japan, "RNA interference (RNAi) is the process by which double-stranded RNA directs sequence-specific degradation of mRNA. In mammalian cells, RNAi can be triggered by 21-nucleotide duplexes of short interfering RNA (siRNA). We examined effects of siRNA on hepatitis B virus (HBV) replication." "Human hepatoma cells were transfected with HBV DNA and siRNA against HBV-pregenome RNA. Transfection experiments demonstrated that the siRNA reduced the amount of HBV-pregenome RNA and resulted in reduction of the levels of replicative intermediates and viral protein,"...
Source: Gene Therapy Weekly (2003-07-24)
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