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Neuroscience
Endogenous amyloid precursor protein modulates apoptosis in neurons
July 24th, 2003
Endogenous amyloid precursor protein modulates apoptosis in neurons. According to recent research published in the journal Experimental Cell Research, "The amyloid precursor protein (APP) is a transmembrane protein whose abnormal processing is associated with the pathogenesis of Alzheimer's disease. In this study, we examined the expression and role of cell-associated APP in primary dorsal root ganglion (DRG) neurons. When dissociated DRG cells prepared from mouse embryos were treated with nerve growth factor (NGF), neuronal APP levels were transiently elevated." "DRG neurons treated with an antibody against cell surface APP failed to mature...
Source: Gene Therapy Weekly (2003-07-24)
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