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Proteomics
Single-stranded DNA aptamers probe cells for protein locales
July 24th, 2003
Single-stranded DNA aptamers probe cells for protein locales. According to published research from the United States, "The accurate localization of proteins in fixed cells is important for many studies in cell biology, but good fixation is often antagonistic to good immunolabeling, given the density of well-preserved cells and the size of most labeled antibody probes." "We therefore explored the use of single-stranded oligonucleotides (aptamers), which can bind to proteins with very high affinity and specificity but which are only approximately 10 kD. To evaluate these probes for general protein localization, we sought an aptamer that binds to a...
Source: Gene Therapy Weekly (2003-07-24)
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