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Rheumatology
Electric pulses aid direct gene transfer into rodent cartilage
July 24th, 2003
Electric pulses aid direct gene transfer into rodent cartilage. According to recent research published in the FASEB Journal, "To establish a system for efficient direct in vivo gene targeting into rat joint, we have evaluated a strategy of gene transfer by means of the delivery of external electric pulses (EP) to the knee after intra-articular injection of a reporter gene (GFP)." "Rats were killed at various times after the electro gene therapy to analyze GFP gene expression by immunohistochemistry. GFP staining was detected in the superficial, middle, and deep zones of the patellar cartilage at days 2 and 9, and thereafter only in the deep...
Source: Gene Therapy Weekly (2003-07-24)
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