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Vector Development
Knowledge of innate response to adenoviruses could accelerate their use
July 24th, 2003
The knowledge of innate response to adenoviruses could accelerate their use in human gene therapies. "Adenovirus vectors are extensively studied in experimental and clinical models as agents for gene therapy. Recent generations of helper-dependent adenovirus vectors have the majority of viral genes removed and result in vectors with a large carrying capacity, reduced host adaptive immune responses and improved gene transfer efficiency. Adenovirus vectors, however, activate innate immune responses shortly after administration in vivo," scientists in Canada report. "Unlike the adaptive response, the innate response to adenovirus vectors is...
Source: Gene Therapy Weekly (2003-07-24)
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