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Virology
Avian adeno-associated virus diverges from but resembles other dependoviruses
July 24th, 2003
Avian adeno-associated virus diverges from but resembles other dependoviruses. "Recent studies have proposed that adeno-associated viruses (AAVs) are not evolutionarily linked to other mammalian autonomous parvoviruses but are more closely linked to the autonomous parvoviruses of birds. To better understand the relationship between primate and avian AAVs (AAAVs), we cloned and sequenced the genome of an AAAV (ATCC VR-865) and generated recombinant AAAV particles. The genome of AAAV is 4,694 nucleotides in length and has organization similar to that of other AAVs," scientists in the United States reported. "The entire genome of AAAV displays 56 to 65%...
Source: Gene Therapy Weekly (2003-07-24)
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