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Virology
Differentiation of HSV thymidine kinase gene length has clinical importance
July 24th, 2003
Differentiation of HSV thymidine kinase gene length has clinical importance. "Allogeneic donor T lymphocytes manipulated genetically to express the herpes simplex virus thymidine kinase (HSV-TK) gene have emerged as promising tools to alter the balance between graft versus host disease and graft versus leukemia after allogeneic stem cell transplantation, since they can be eliminated selectively in vivo with ganciclovir," according to a study from the Netherlands. "Recently, it was reported that in SFCMM-3, an HSV-TK-encoding retroviral vector, two cryptic splice sites in the HSV-TK sequence led to the generation of an HSV-TK splice variant...
Source: Gene Therapy Weekly (2003-07-24)
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