Gene Therapy Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Cardiac Transplantation
Feline immunodeficiency virus-mediated gene transfer prolongs graft survival
July 24th, 2003
Feline immunodeficiency virus-mediated gene transfer prolongs graft survival. According to a study from the United States, "Previous experiments demonstrated plasmid-, retro-, viral-, or adenoviral-mediated vIL-10 gene transfer could prolong allograft survival, but transgene expression was rapidly extinguished. Feline immunodeficiency virus (FIV) can integrate into genomic DNA of nondividing cells, resulting in indefinite transgene expression. We hypothesized FIV-mediated gene transfer could provide long-term gene expression, and improved allograft survival." "FIV-vIL-10 and FIV-beta-gal were produced using the FELIX vector system. With vector...
Source: Gene Therapy Weekly (2003-07-24)
|
