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Vector Development
A novel method discerns the quality of transgene expression in vector stocks
July 24th, 2003
A novel method discerns the quality of transgene expression in vector stocks. According to recent research from Belgium, "The development of vectors for gene therapy requires the definition of quality control parameters such as titration, contamination, transduction efficiency and biological effects in defined model systems. For most viral vectors, the classical titration by plaque formation is not applicable, because vectors are defective for replication and packaging cell lines are not always available." "In particular, for vectors derived from the autonomous parvovirus MVM(p), the titration method used currently is based on the amplification of...
Source: Gene Therapy Weekly (2003-07-24)
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