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Drug Delivery
Nanoparticles potentially useful vehicles
July 24th, 2003
Tiny cages made out of a viral protein show great promise as a way of delivering genes or drugs to the liver. The new method, described in the August 2003 issue of Nature Biotechnology, may be useful for treating various liver diseases with beneficial genes or drugs. The cages, or nanoparticles, form spontaneously when a single protein from hepatitis B virus is produced in large quantities. Kuroda and colleagues were able to put genes or proteins inside such nanoparticles using pulses of electric current. They then injected the nanoparticles into mice that had been transplanted with small human liver tumors. The nanoparticles traveled...
Source: Gene Therapy Weekly (2003-07-24)
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