Hepatitis B Therapy
RNA interference suppresses HBV replication in cell cultures and animal liver
Published in Gene Therapy Weekly, July 31st, 2003
"Hepatitis B virus (HBV) infection substantially increases the risk of chronic liver disease and hepatocellular carcinoma in humans. RNA interference (RNAi) of virus-specific genes has emerged as a potential antiviral mechanism. Here we show that RNAi can be applied to inhibit production of HBV replicative intermediates in cell culture and in immunocompetent and immunodeficient mice transfected with an HBV plasmid," scientists in the United States report.
"Cotransfection with plasmids expressing short hairpin RNAs (shRNAs) homologous to HBV mRNAs induced an RNAi response....
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2003-07-31)
More Articles from Gene Therapy Weekly
- Gastroenterology
Pancreatic tumors become susceptible to toxin when made to express IL-13Ralpha2 - Glioma
Interferon-beta gene transfer accompanied by dendritic cells inhibits cancer - Gene Delivery
Polyethylene glycol augments the effects of liposome-mediated gene transfer - Gene Interference
Second generation synthetic siRNAs will be better suited for gene silencing - Pulmonary Medicine
Vector complexes formed in water enhance pulmonary gene expression in vivo - Virology
Plasma-based titrations can miss the full extent of adenovirus circulation - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
