Virology
Plasma-based titrations can miss the full extent of adenovirus circulation
Published in Gene Therapy Weekly, July 31st, 2003
According to published research from Germany, "recombinant adenoviruses are presently the most efficient in vivo gene transfer system available. Targeting single organs or large tumors by adenoviral vectors requires an intravascular route of application. During the first pass of viral particles through the vascular bed of the target tissue, virus uptake is not quantitative and undefinite amounts of particles leak into circulation."
"To determine the amount of leaking particles and to calculate organ-specific uptake (in-/outflow ratio), it is necessary to titrate virus...
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Source: Gene Therapy Weekly (2003-07-31)
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