Published in Gene Therapy Weekly, July 31st, 2003
"Activation of T cells from patients with systemic lupus erythematosus (SLE) leads to increased signaling responses, detected by increased calcium and protein tyrosine phosphorylation patterns. This overexcitability occurs in spite of decreased levels of T-cell receptor zeta chain," investigators in the United States report.
"The replacement of the zeta chain by the Fc receptor (FcR) gamma chain and the formation of signaling molecule aggregates on the surface of T cells are considered to be responsible for the observed signaling phenotype," according to G.C. Tsokos and colleagues,...
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