Cancer Therapy

Targeting Ki-67 mRNA is an effective strategy for preventing tumor growth

Published in Gene Therapy Weekly, August 7th, 2003

Targeting Ki-67 mRNA is an effective strategy for preventing tumor growth.

"The Ki-67 protein is tightly regulated and depends on the proliferative status of a cell. It is present in the nuclei of proliferating cells but absent in resting cells. Since transformation of malignant cells is frequently associated with high cell proliferation and since proliferation is tightly associated with the Ki-67 protein labeling index, this antigen may represent a potential target for cancer therapy," scientists writing in the International Journal of Cancer report.

"In the present study we determined the ability of a phosphorothioate antisense...

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Source: Gene Therapy Weekly (2003-08-07)

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