Chemotherapy

Gene and prodrug therapy won't override ABCG2-mediated drug resistance

Published in Gene Therapy Weekly, September 11th, 2003

Gene and prodrug therapy won't override ABCG2-mediated drug resistance.

According to recent research published in the journal Molecular Pharmacology, "the recently introduced camptothecin-derived chemotherapeutic agents have demonstrated remarkable promise in cancer therapy and as such have been approved for use in humans for the treatment of ovarian, lung, and colon cancer. CPT-11 is a prodrug that is activated by esterases to yield the potent topoisomerase I inhibitor, SN-38. Considerable success has been achieved in the treatment of both naive and drug-resistant colon cancer with CPT-11."

"However, mechanisms of resistance to this agent...

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Source: Gene Therapy Weekly (2003-09-11)

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