Ovarian Cancer
Epithelial ovarian carcinomas overexpress high mobility group A 1 proteins
Published in Gene Therapy Weekly, September 18th, 2003
"High mobility group A 1 (HMGA1) proteins are chromatinic factors, which are absent or expressed at very low levels in normal adult tissues, while they are overexpressed in several human malignant tumors. In this study, HMGA1 protein expression was investigated by immunohistochemistry in a series of 44 epithelial ovarian specimens, which included four normal ovarian tissues, 29 primary invasive carcinomas, one metastatic ovarian tumor and 10 low malignant potential (LMP) tumors. HMGA1 staining was not detected in normal ovarian surface epithelium, which is the area from which ovarian...
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Source: Gene Therapy Weekly (2003-09-18)
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