Neurodegeneration
Increased peroxiredoxin-3 could protect hippocampal neurons from injury
Published in Gene Therapy Weekly, September 25th, 2003
"Mitochondria are involved in excitotoxic damage of nerve cells. Following the breakdown of the calcium-buffering ability of mitochondria, mitochondrial calcium overload induces reactive oxygen species (ROS) bursts that produce free radicals and open permeability transition pores, ultimately leading to neuronal cell death. In the present study, we focused on a mitochondrial antioxidant protein, peroxiredoxin-3 (Prx-3), to investigate the mechanism by which toxic properties of ROS were up-regulated in mitochondria of damaged nerve cells," researchers in Japan reported.
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Source: Gene Therapy Weekly (2003-09-25)
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